Pathway analysis of double-negative RA patients with healthy controls revealed the activation of the coagulation system (p = 7.94 × 10−19), the intrinsic prothrombin activation pathway (p = 5.01 × 10−12) and the extrinsic prothrombin activation pathway (p = 1.25 × 10−13); and inhibition of the LXR/RXR pathway (p = 1.58 × 10−25); acute phase response signalling (p = 1 × 10−23) and production of NO and ROS in macrophages (p = 2.18 × 10−10) (Figure 5D). The gene discussed is F2; the disease is rheumatoid arthritis.