MAPT and Alzheimer disease: Both forms of dementia exhibit common neuropathological hallmarks of amyloidopathy and tauopathy characterized by intracellular neurofibrillary tangles (NFTs), formed by hyperphosphorylation of tau protein in microtubules and neurofilaments, and extracellular deposits of aggregated β-amyloid (Aβ) in senile plaques and vessels (amyloid angiopathy), and probably exert synergistic effects on AD pathogenesis [10].