The genes that most frequently accumulate pathogenic variants (>50%) in cases of AD are the following: PRNP (80.70%), ACE (78.94%), PSEN1 (77.19%), CLU (63.15%), CPZ (63.15%), MS4A6A (63.15%), BIN1 (57.89%), A2M (54.38%), PICALM (54.38%), LHFPL6 (52.63%), and MS4A4E (50.87%) (Figure 3). This evidence concerns the gene PICALM and Alzheimer disease.