In human medulloblastoma and breast cancer cell lines, the Notch-mediated upregulation of HIF-2α was accompanied by downregulation of HIF-1α, which the authors postulated may drive the potential transition from shorter-term HIF-1α supported responses to hypoxia to the more sustained responses characterized by HIF-2α signaling [93]. The gene discussed is HIF1A; the disease is medulloblastoma.