TBX21 and peripheral T-cell lymphoma, not otherwise specified: GATA3 is the master regulator in T-helper 2 (TH2) cell differentiation and regulates IL-4, Il-5, and IL-13 expression, whereas TBX21 is the master regulator of TH1 and cytotoxic T-Cell differentiation and regulates interferon-gamma and granzyme B. Based on this differentiation, two distinct peripheral T-Cell lymphoma groups, PTCL-GATA3 and PTCL-TBX21, have emerged [53].