CD274 and lymphoma: In 2019, Mikkelsen et al. [69] investigated the effect of B vitamins on the modulation of the immune response, they found that vitamin B6 exerted anti-proliferative and anti-migratory activities in promonocytic lymphoma cell lines, likely by decreasing the expression of PD-L1, indicating the potential of vitamin to improve the efficiency of PD-1/PD-L1 blockade.