Additionally, Parkin-independent mitophagy was also significantly downregulated in NASH-induced cardiotoxicity group, as shown by significant reduction in ULK1, BINP3L and FUNDC 1 gene expressions by 0.7-, 0.47- and 0.35-fold, respectively, when compared to the control group (Figure 6E–G). The gene discussed is PRKN; the disease is metabolic dysfunction-associated steatohepatitis.