Furthermore, Japanese children diagnosed with Fanconi anemia progressed more rapidly to bone marrow failure; the median time to the development of aplastic anemia was 72 months after birth in patients with homozygous wild-type ALDH2*1 genotype, relative to only 28 months in heterozygous ALDH2*1/*2 genotype, and 0 months (range 0–7) in homozygous ALDH2*2 genotype [74,75]. Here, ALDH2 is linked to Fanconi anemia.