KRT8 and Oral leukoplakia: In addition, K8 expression was detected in the early stages of the disease, that is, the dysplastic oral leukoplakia, but in not the normal or hyperplastic epithelium of the head and neck area, including the normal mucosa, hyperplastic and dysplastic leukoplakia, carcinomas, and lymph node metastases [64], as well as in carcinomas originating from other regions except those of the larynx and the tongue.