INS and diabetes mellitus: In contrast, the results presented by Holman et al. [69] in 2008 of the 10-year follow-up of participants in the United Kingdom Prospective Diabetes Study (UKPDS) in the sulfonylureas-insulin group, relative risk reductions persisted for microvascular disease (p = 0.04), but this effect was not seen in the metformin group of patients with TIIDM.