LCN2 and acute kidney injury: In the STARRT-AKI study, the NGAL level ≥ 400 ng/mL, along with a twofold increase in serum creatinine and oliguria, was used to guide the early start of KRT; the results were not as expected, because the early initiation of KRT in patients with NGAL levels ≥ 400 ng /mL had no effect on mortality.