It has been shown that high levels of FETU-A can be considered a risk factor for insulin resistance, T2DM, CVD by inhibition of adiponectin expression, peroxisome proliferator-activated receptor-γ (PPARγ) or activating the toll-like receptor 4 (TLR-4), and as a factor reducing the risk of coronary artery disease [41]. The gene discussed is TLR4; the disease is Insulin resistance.