Nerve oedema, originating from an increased vascular permeability and angiogenesis, due to upregulation of vascular endothelial growth factor (VEGF) in diabetes, may also contribute to the increased susceptibility to compression trauma [47]; a mechanism that has been related to increased endoneurial pressure with a risk of jeo-pardised blood supply to the nerve fibres in the fascicles [48]. Here, VEGFA is linked to diabetes mellitus.