The addition of PGF2α or OMD induced a significant down-regulation of TIMP1 (2D and 3D), TIMP3 (3D), MMP14 (3D), GRP 78 (2D), GRP 94 (2D), XBP (2D), sXBP (2D), and CHOP (2D and 3D) and an up-regulation of CTGF (2D) and a down-regulation of TIMP3 (3D) as well as all five ER stress-related genes (2D), and an up-regulation of CTGF (2D), respectively (Supplemental Figures S3–S5). The gene discussed is MMP14; the disease is occult macular dystrophy.