The addition of PGF2α or OMD induced a significant up-regulation in COL4 (2D) and a down-regulation in COL1 (3D), COL6 (3D), FN (3D), and αSMA (3D), and a substantial up-regulation of COL4 (2D) and down-regulation of COL6 (3D) and FN (3D), respectively (Figure 4). Here, ACTA1 is linked to occult macular dystrophy.