To elucidate the underlying mechanisms responsible for the above effects by PGF2α and OMD on the TGF-β2-treated 2D- and 3D-cultured HTM cells, the expression of ECM proteins (COL1, 4, and 6, FN, and αSMA) was estimated by qPCR analysis and immunolabeling. This evidence concerns the gene TGFB2 and occult macular dystrophy.