The current study examines: (i) the effect of diet on pulmonary pathology; (ii) the effect of Mtb infection on the development of insulin resistance in juvenile and adult mice, and (iii) the role of adipose tissue in regulating pulmonary pathology and insulin sensitivity during Mtb infection in mice of different age groups and fed either a control carbohydrate rich diet or a high fat diet. The gene discussed is INS; the disease is Insulin resistance.