Because activated macrophages secrete elastase, which cleaves adiponectin to form pro-inflammatory globular adiponectin fragments [31,32], we analyzed the effect of infection and diet on inflammatory signaling by measuring the levels of F4/80 (macrophage marker) and TNFα and IFNγ in the WAT of juvenile and adult mice fed different diets (Figure S4). The gene discussed is IFNG; the disease is infection.