Our aims were, firstly, to compare cardiovascular risk markers (blood pressure, resting heart rate, endothelial function, IMT, and circulating concentrations of lipids, glucose, insulin, and MMP-9) between women with and without PCOS, and secondly, to assess the effect of 16 weeks of HIIT on these markers in both groups of women. The gene discussed is INS; the disease is polycystic ovary syndrome.