AKT1 and breast cancer: Finally, multivariate Cox analyses demonstrated that p-AKT is an unfavorable independent factor associated with both OS (Hazard ratio (HR)= 3.25; 95% confidence interval (CI), 1.5–7.2; p = 0.003) (Table 2) and EFS (HR = 2.8; 95% CI, 1.3–6.1; p = 0.008) (Table S3) in early breast cancer.