Caveolin-3 exerts its effects as a scaffolding and regulatory protein for signaling molecules and moderators of ion channels and has already been linked to numerous human disease states, such as long QT syndrome, sudden infant death syndrome, myocardial hypertrophy, and diabetic cardiomyopathy [8,9,10] (Table 1). This evidence concerns the gene CAV3 and Prolonged QT interval.