Caveolin-3 overexpression could lead to the reduced diastolic spontaneous Ca2+ waves by inhibiting the hyperphosphorylation of ryanodine receptor-2 (RyR2) at Ser2814, thus leading to the abnormal LTCC current-induced ventricular arrhythmias [64]. This evidence concerns the gene RYR2 and Ventricular arrhythmia.