GH1 and Intellectual disability: It is a multisystemic and very heterogeneous syndrome that involves multiple symptoms: (1) physical: severe neonatal muscular hypotonia, a peculiar face, and a hypothalamic deficit, among which the growth hormone (GH) stands out; (2) behavioral: hyperphagia and insatiable food-seeking behavior, skin picking, ritualistic and obsessive compulsive behaviors, and emotional lability; (3) cognitive: intellectual disability, with an average intelligence quotient (IQ) between 55–60 and 70, and a verbal quotient usually below the manipulative quotient.