Number of SAE lower for TCZ than PBO (OR 0.539, 95% CI 0.296–0.982, p = 0.044).NS difference in SAE among patients treated with TNF antagonists, ABA and PBO.Infection rate higher for TNF antagonists than PBO (OR 2.407, 95% CI 1.168-4.960, p = 0.017), but with NS differences between TCZ, ABA and PBO. The gene discussed is TNF; the disease is infection.