The polymorphism of genes for interleukins (IL) such as IL1A, IL1B, IL4, IL6, IL8, IL10, IL17A, IL17F, and related antagonists and receptors IL1RN, IL4R, IL17RB, and IL23R family genes are also responsible for the develop inflammation during acne vulgaris [47]. This evidence concerns the gene IL1A and acne.