The prescription information of Sativex, a cannabis extract preparation approved for symptomatic treatment of multiple sclerosis patients, warns that CYP3A4, 1A2, 2B6, 2C9, and 2C19 are inhibited, and the mRNA expression of CYP1A2, 2B6, and CYP3A4 is induced [60]. The gene discussed is CYP3A4; the disease is multiple sclerosis.