The administration of intravenous recombinant tissue plasminogen activator (IVT) within the first hours after stroke onset is a standard of care in ischemic stroke, and is often used in combination with endovascular thrombectomy (EVT), which has proven to be beneficial to patients with ischemic stroke caused by a large vessel occlusion (LVO) in the anterior circulation [1,2,3,4]. This evidence concerns the gene PLAT and ischemic stroke.