The role of the sFlt-1/PIGF ratio has been documented previously in several studies conducted on type 1 and type 2 diabetes mellitus [53,54]; recently, Nuzzo et al. [37] have also identified an increased placental and maternal sFlt1/PlGF ratio in women with GDM who develop preeclampsia. The gene discussed is PGF; the disease is type 2 diabetes mellitus.