Our results revealed no differences in both of these biomarkers in pregnancies complicated by IUGR among women who developed HDP, but we did find that the sFlt-1/PIGF ratio was negatively correlated with the week of pregnancy at delivery and the weight of the newborn in women with GDM who developed subsequent HDP, both of which were consistent with those reported by other authors [47,48]. This evidence concerns the gene PIGF and fetal growth restriction.