In terms of perinatal outcomes, the hypothesis exists that preeclampsia and IUGR are linked etiologically but have different clinical manifestations [43,44,45]; the link among lower PlGF and higher sFlt-1 levels in IUGR newborns of mothers with preeclampsia has been previously described [40,41,45,46]. The gene discussed is PGF; the disease is fetal growth restriction.