With increased application of percutaneous LAAC therapies for stroke prophylaxis, it is currently unknown whether elimination of atrial natriuretic peptide (ANP) secretion from the LAA may have adverse effects on long-term physiological regulation of fluid volume, brain natriuretic peptide (BNP), salt-water balance, renin-angiotensin-aldosterone system (RAAS), adrenergic system, and blood pressure (BP). This evidence concerns the gene NPPA and stroke disorder.