Interestingly, in this research study, the gene-expression assay of the bone tissue surrounding the implants demonstrated that the use of a modified implant macrodesign in DM animals promoted the upregulation of the OPN levels with a significative augment when compared with samples from the DM animals that had received conventional implants (p < 0.05), as also observed in Non-DM animals (p < 0.05). Here, SPP1 is linked to diabetes mellitus.