There were decremental linear trends in fasting blood glucose (p = 0.018), insulin (p < 0.001), HOMA-IR (p < 0.001), TG (p = 0.002), and the prevalence of MetS (p < 0.001) in conjunction with incremental linear trends in HDLC (p < 0.001) and vitamin D (p < 0.001) by eCRF levels. This evidence concerns the gene INS and metabolic syndrome.