There were decremental linear trends in fasting blood glucose (p < 0.001), insulin (p < 0.001), HOMA-IR (p < 0.001), TG (p < 0.001), and the prevalence of MetS (p < 0.001) in conjunction with incremental linear trends in HDLC (p < 0.001) and vitamin D (p < 0.001) by eCRF levels. The gene discussed is INS; the disease is metabolic syndrome.