Insulin-dependent DM of WS1 differs from common type 1 DM (T1D) in the following features: earlier diagnosis, rarely positive autoantibodies, rare ketoacidosis, longer remission periods, lower daily requirement of insulin, mean values of HbA1c lower than T1D, and frequent episodes of hypoglycemia [10,23,56]. This evidence concerns the gene INS and type 1 diabetes mellitus.