Taken together, the most prominent activated pathways in endometrial cancer stem cells include Wnt/β-Catenin, PI3K/AKT signaling and Notch signaling in crosstalk with other signaling pathways like NF-κB, which leads to the upregulation of genes associated with stemness, resistance and EMT (Figure 1). Here, NFKB1 is linked to endometrial cancer.