PLIN2 and neoplasm: IL1RAPL2 belongs to the interleukin-1 receptor (IL-1R) family, PLIN2 encodes perilipin 2 (also called adipophilin or adipose differentiation-related protein), SMAD3 plays an important role in regulating glucose energy homeostasis, and TSC1 is a critical tumour suppressor in mTOR pathway.