The proliferation of macrophages leads to macrophage accumulation in the course of obesity development and is followed by greater migration and aggravated accumulation of macrophages in adipose tissue (mediated by the CCL2/IL-1β/C-X-C motif chemokine ligand 12 (CXCL12) signalling pathway) [110,111]. Here, CXCL12 is linked to obesity disorder.