The analysis of the impact of hypermethylation of 20 genes related to obesity on renal carcinogenesis and prognosis revealed that genes of neuropeptide Y, leptin, and leptin receptor were considerably more hypermethylated compared to normal adjacent parenchyma tissue (p < 0.0001) [203]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.