In turn, the examination of the promoter methylation status of 10 biologically significant tumour suppressor and cancer genes (VHL, p16(INK4a), p14(ARF), APC, MGMT, GSTP1, RARbeta2, RASSF1A, E-cadherin, and Timp-3) in 100 kidney tumours demonstrated the occurrence of hypermethylation in all of the histological cell types and grades and stages [204]. This evidence concerns the gene CDKN2A and cancer.