The crosstalk between adipocytes and cancer cells have been found to induce morphological and functional alterations, including the delipidation of adipocytes, enhanced release of proinflammatory molecules (PAI-1, IL-6 and IL-8) and reduction in adipocyte terminal differentiation markers; therefore, cancer-related adipocytes gain a fibroblast-resembling and cancer-promoting phenotypes [150,151]. Here, SERPINE1 is linked to cancer.