SMPD1 and Anxiety: The pharmacological inhibition of ASM activity via administration of functional inhibitors of ASM (FIASMAs) [38], such as amitriptyline and fluoxetine, reduced hippocampal ceramide concentrations, increased neurogenesis and exerted antidepressant and anxiolytic-like effects in mice exposed to chronic unpredictable mild stress [25,27] and in ASMtg mice [25] but not in ASM−/− mice [25], further supporting the critical involvement of ASM in anxiety- and depressive-like behavior.