CRP and ischemic stroke: In addition, selective exosomal miRNAs were shown to be significantly increased in ischemic stroke, with some miRNAs showing potentials of differentiating between early acute phase and recovery phase [42,43], while elevated serum expression levels of certain miRNAs showed correlation with high sensitivity C-reactive protein (hs-CRP) and MMP-9 in ischemic stroke patients [44].