B3GAT1 and acute myeloid leukemia: Likewise, in Acute Myeloid Leukemia (AML) patients, the gene expression profile of peripheral CD8+ T cells showed a premature senescent phenotype, characterized by the expression of CD57, and an exhausted state, supported by the upregulation of PD-1 and CTLA-4, which was remarkably enhanced after chemotherapy [100].