ITGAM and amyotrophic lateral sclerosis: A previous study from our group using unbiased proteomics of peripheral blood mononuclear cells and matched biofluids from individuals living with ALS has identified the regulation of beta-1, beta-3 and alpha-M integrins in white blood cells and plasma from ALS patients [27,28], suggesting a role for these mediators in the immunological crosstalk between peripheral circulation and inflamed brain tissue.