TARDBP and amyotrophic lateral sclerosis: In ALS, monocytes have been reported to have an enhanced migratory behavior and to display a transcriptional profile skewed toward a proinflammatory state, particularly in individuals with a faster disease progression (A-F) [14,15,19,20] Cytoplasmic accumulation of the nuclear protein transactive response DNA-binding protein 43 (TDP-43), a hallmark of ALS pathology, has also been described in monocytes, monocyte-derived macrophages and microglia [21].