In agreement with our findings with HIV-Tg mice, we have shown that frequencies of MZp are increased in the blood of HIV-infected individuals from the Montreal primary HIV infection (PHI) cohort, as soon as in the acute phase, and despite HAART; they are concomitant with excessive BAFF levels which persist throughout, suggesting that deregulations of MZ population frequencies in the HIV context could involve excess BAFF [5,6]. The gene discussed is TNFSF13B; the disease is HIV infectious disease.