STAT3 and brain neoplasm: Moreover, in medulloblastoma (commonest type of primary brain tumor in children) RES showed suppression of cell growth through STAT3 downregulation, reducing the incidence of STAT3 nuclear translocation and promoting neuronal differentiation of cell growth medulloblastoma through axon regeneration and SOCS3 accumulation at the synapse-like end of long cellular processes [149].