Hyperactivation of the Akt/mTOR pathway is known to support the highly invasive phenotype of GSC, while inhibition of mTOR results in a reduction in both mRNA, protein levels, and matrix metalloproteinase (MMP) activity MMP-9 and MMP-2, which enhance tumor invasiveness by degradation of the extracellular matrix [96]. This evidence concerns the gene MTOR and neoplasm.