In COVID-19 clinical practice, in addition to the global markers PT, APTT, fibrinogen, FDP, D-dimer, and AT, the coagulation activation marker TAT, the fibrinolysis activation marker PIC, plasminogen, and the alpha2 plasmin inhibitor (alpha2 PI) (α2PI < 50% increases the risk of bleeding) should also be measured [93]. Here, PLG is linked to COVID-19.