In addition to D-dimer, other markers predicting poor prognosis include lymphocytopenia [59,60], thrombocytopenia [59,60], elevated C-reactive protein [61,62], elevated IL-6 [60,61,62], elevated lactate dehydrogenase (LDH) [63], elevated ferritin [60], sphingolipid profile [64], increases in soluble tumor necrosis factor or its receptor, or an increase in a disintegrin and metalloproteinase 17 (ADAM17) [65]. The gene discussed is ADAM17; the disease is Thrombocytopenia.