HIF1A and Hyperglycemia: Results showed a statistically significant increase in HIF1α activity in the case of the 1BR.3.N WWOX KO transductant compared to the 1BR.3.N CONTR under the conditions of normoxia normoglycemia (p < 0.01), normoxia hyperglycemia (p < 0.05) and hypoxia hyperglycemia (p < 0.01) (Figure 2).