It was also confirmed that 1BR.3.N WWOX overexpression cells showed a significant reduction in HIF1α activity under all tested conditions, by about 50% in normoxia normoglycemia (p < 0.05), by about 70% in normoxia hyperglycemia (p < 0.05), and almost 6.5-fold decrease in HIF1α activity under hypoxic conditions (p < 0.001), both in standard and elevated glucose concentration in the culture medium (Figure S1a). Here, HIF1A is linked to Hyperglycemia.