HK2 and Hyperglycemia: Additionally, it was observed that 1BR.3.N WWOX OE cell line variant demonstrated reduction of PKM2 and LDHA protein expression in normoxia normoglycemia, decrease of HK2 protein in normoxia hyperglycemia, and PKM2 reduction in hypoxia hyperglycemia condition relative to 1BR.3.N WT cell line variant (Figure S4).