HK2 and Hyperglycemia: The present study demonstrated that 1BR.3.N WWOX KO variant exhibits higher HK2 (p < 0.01) and LDHA (p < 0.01) protein expression in normoxia normoglycemia, lower PKM2 (p < 0.05) in normoxia hyperglycemia, and lower PKM2 (p < 0.05) and LDHA (p < 0.01) in hypoxia hyperglycemia in comparison to 1BR.3.N CONTR (One repetition is shown in the Figure 7).