PKM and Hyperglycemia: Additionally, we observed in 1BR.3.N WWOX OE cell line variant the reduction of PKM2 and LDHA protein expression in normoxia normoglycemia, the decrease of HK2 protein in normoxia hyperglycemia, and PKM2 reduction in hypoxia hyperglycemia condition relative to 1BR.3.N WT cell line variant (Figure S5).