Pretreated with insulin, the 1BR.3.N WWOX OE fibroblasts, showed a significant (p < 0.05) increase in glucose uptake in the normoxia hyperglycemia, but glucose uptake decrease in hypoxia normoglycemia and hyperglycemia in comparison to 1BR.3.N WT (Figure S1b). This evidence concerns the gene INS and Hyperglycemia.