The western blot analyses found that the level of the WWOX protein is significantly depleted in a cytoplasmic fraction in all tested conditions in case 1BR.3.N WWOX KO in comparison to CONTR (more than 4-fold for normoxia normo- and hyperglycemia, both p < 0.001; 3-fold for hypoxia normo- and hyperglycemia conditions, both p < 0.01). The gene discussed is WWOX; the disease is Hyperglycemia.