In normoxia hyperglycemia conditions, lactate dehydrogenase activity (p < 0.01) and lactate level (p < 0.001) was still upregulated in 1BR.3.N WWOX KO cells in comparison to 1BR.3.N CONTR but did not contribute to the changes in hexokinase, pyruvate dehydrogenase, and citrate synthase activity under these conditions. The gene discussed is CS; the disease is Hyperglycemia.