Despite the accumulated knowledge and technological achievements in amyloid beta (Aβ) and tau detection which build up in the AD brain and typify AD pathology and the new FDA-accelerated approval of the controversial disease-modifying drug Aducanumab (marketed as Aduhelm), which likely can reasonably translate to a clinical benefit [8], the current consensus in the field is that the cause of AD is incompletely defined. This evidence concerns the gene MAPT and Alzheimer disease.