It appears that none of the new validated degron motifs have increased cancer-associated somatic mutation rate (based on COSMIC data analysis, not shown), possibly because their loss-of-function effect is individually not strong enough, albeit the degrons located in the MYC proto-oncogene and KLF5 were found to be a hot-spot in B-cell lymphomas or colorectal cancer, respectively [60,61]. The gene discussed is KLF5; the disease is colorectal cancer.