Recent data from ERA registry presented lower prevalence of ADPKD ranging from 3.96/10,000 [1], but the study using measurement of frequency of high-confident mutations of ADPKD genes (PKD1 and PKD2) in databases gnomAD and BRAVO estimated higher prevalence 9.3/10,000 [2]. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.