TNF and metabolic dysfunction-associated steatotic liver disease: In fact, increased susceptibility to liver injury and the aggravation of hepatic lesions in obese and NAFLD patients could be attributable to underlying mitochondrial dysfunction (latent ETC dysfunction), reduced antioxidant defenses (low GST expression and GSH levels), the enhanced expression and activity of CYP isoenzymes (CYP2E1), and pro-inflammatory and pro-fibrotic cytokine production (tumor necrosis factor α; TNF-α) [169,170,171,172,173].