Acts of D609 due to PC-PLC inhibition include the inhibited post-stroke production of hypoxia-inducible factor 1-alpha (HIF-1 α), the protection of tumor necrosis factor (TNF-α) or lethal shock mediated by LPS in mice, diminished expression of cytokines in macrophages induced by lipopolysaccharide (LPS) and safeguarding immature neurons (non-expressed glutamate receptors) against oxidative toxic glutamate [33]. The gene discussed is TNF; the disease is Stroke.