To explore the mechanism of these changes, we investigated the role of sequestosome 1/p62 (SQSTM1/p62, hereafter referred to as p62) in ovarian cancer cells and found that p62 formed a “death platform” with autophagosome membranes to recruit Caspase 8 and regulate its activation in ovarian cancer cells [6]. The gene discussed is SQSTM1; the disease is ovarian carcinoma.