TP53 and ovarian cancer: In conclusion, our study provides evidence that inhibition of the proteasome pathway altered the mitochondrial localization of p53, downregulated the gene expression of mitochondrial respiratory chain subunits to impair mitochondrial functions, promoted the sensitivity of ovarian cancer cells to cisplatin, and promoted mitochondrion-dependent apoptosis, which was coordinated by the UBA domain of p62 (Figure 8).