Indeed, RA synovial fibroblasts, cancer-associated fibroblasts (CAFs) and activated myofibroblasts have all previously been shown to increase their rate of glycolysis and increase their expression of key glycolytic enzymes, such as Phosphofructokinase (PFKL), PFKFB3 and phosphoglycerate kinase 1 (PGK1) when in inflammatory micro-environments, in order to meet the energy demands of cell [15,17,18,19,32]. This evidence concerns the gene PFKFB3 and cancer.