PFKFB3 and pulmonary fibrosis: Similarly, in pulmonary fibrosis, activated myofibroblasts exhibit increased expression of the glycolytic enzyme phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme (PFKFB3), and use of a PFKFB3 inhibited attenuated the differentiation of lung fibroblasts into activated fibroblasts [17].