EPHA2 protein expression was reported to be upregulated in EC tissue samples, while its overexpression was significantly associated with high tumor stage and grade, increased depth of myometrial invasion, low estrogen receptor (ER) and progesterone receptor (PR) expression, high Ki67 index, high vascular endothelial growth factor (VEGF) expression, high MVD counts, and shorter disease-specific survival [58,59]. This evidence concerns the gene ESR1 and neoplasm.