PSEN1 and Alzheimer disease: The pooled results of regular PA, recently studied in a variety of AD rodent models (mice overexpressing a mutant form of APP or a human presenilin 1 and a chimeric amyloid precursor protein; streptozotocin or Aβ peptide brain infusion elicited AD), are: (a) the preferred training method was forced treadmill running, exercise intensity at about 50% of VO2 max; and (b) the training duration was 20–60 min/day, 5–7 days per week, between 1 week and 5 months.