AOPEP and early-onset autosomal dominant Alzheimer disease: Cognition and molecular biomarkers were evaluated in two subgroups of nondemented persons with a family history of Alzheimer’s disease; subgroup + APO ε4 (with APO ε4 genotype) and subgroup—APO ε4 (without the APO ε4 genotype allele), and compared to their senior functional physical fitness test values.