CD8A and neoplasm: The secreted IFNs bind to the heterodimer type I IFN receptors (IFNAR1/IFNAR2) on the dendritic cells (DCs) and activate JAK/STAT signal pathway to express ISGs and pro-inflammatory cytokines, including IFNγ and IP-10 (CXCL10), which contribute to the activation and tumor infiltration of CD8+ T cells.