FBXO32 and Atrophy: In addition, increased expression of muscle-specific miR-1 was found to reduce HSP70 levels, decreasing AKT phosphorylation and leading to activation of FOXO3 and ultimately resulting in the upregulation of MuRF1 and MAFbx/atrogin-1 expression during dexamethasone-induced muscle atrophy in mice [87].