XRCC4 and glioblastoma: XRCC4 is a direct target of miR-151a, and it has been observed that stable overexpression of miR-151a recovered the temozolomide (TMZ) sensitivity of TMZ-resistant glioblastoma (GBM) cells in vitro, thus, demonstrating the importance of miR-151a/XRCC4 signaling in modulating NHEJ repair and TMZ resistance in GBM [48].