Other possible explanations for the conflicting data on the effects of TRAIL on adipose tissue may be related to the experimental models of obesity studied, issues of species- and tissue-specificity, as well as the limited capacity of in vitro experiments to capture the complex crosstalk of adipose tissue with other tissues and reflect the in vivo physiology. The gene discussed is TNFSF10; the disease is obesity due to melanocortin 4 receptor deficiency.