TNFSF10 and age-related macular degeneration: The authors suggested that the low levels of TRAIL-R3 in these patients may actually increase the amount of TRAIL interacting with the proapoptotic receptors (TRAIL-R1 and TRAIL-R2), resulting in enhanced TRAIL-mediated apoptosis of photoreceptors and retinal pigment epithelial cells, which is an important contributor to the pathogenesis of AMD [97].